Buy MPHP for sale in crystals | MPHP Research Chemicals | Mphp powder 100g


Purchase MPHP for sale (RS)-1-(4-methylphenyl)-2-(1-pyrrolidinyl)-1-hexanone or MPHP, as it is commonly known, is a specially formulated compound that is …



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Buy MPHP for sale in crystals – MPHP, an abbreviation of 4′-Methyl-α-pyrrolidinohexiophenone, is a stimulant designer drug compound. MPHP bears a close structural relationship to Pyrovaleron a psychoactive stimulant that acts as a norepinephrine-dopamine reuptake inhibitor prescribed in the treatment of lethargy, chronic fatigue and obesity. To produce MPHP one simply adds one more carbon to the alkyl side chain at the alpha position in Pyrovaleron.

MPHP belongs to the pyrrolidinophenone series of stimulants. The structure activity relationship of the series is as follows. Stimulant activity is produced when the aryl, pyrrolidinyl and ketone functional groups are kept constant. The length of the alkyl chain can be varied between seven to three carbons in length. The greatest potency within the series is found with an alkyl chain of 5 or 6 carbons as is the case with MPHP. A number of substituents may be placed on the aryl ring and the stimulant effect maintained.

Given this trend in structure activity relationship of the pyrrolidinophenone series, and relative dearth of information regarding MPHP itself, it may be presumed to have effects associated with the series. Similar drugs to MPHP such as Pyrovaleron are associated with abuse, addiction potential and psychological dependence. Side effects of the pyrrolidinophenone series are a marked loss in appetite, weight loss and anorexia, fragmented or disturbed sleep, insomnia, tremours, shakes and anxiety. Withdrawal from prolonged use of pyrrolidinophenone drugs often results in negative emotional states and depression.

Pyrrolidinophenones like MPHP tend to act as norepinephrine–dopamine reuptake inhibitors inhibiting the action of the dopamine transporter (DAT) and the norepinephrine transporter (NET). This produces an increased concentration of noepinephrine and dopamine in the synaptic cleft and increases adrenergic and dopaminergic neurotransmission.

MPHP has the formal and systematic IUPAC name (RS)-1-(4-methylphenyl)-2-(1-pyrrolidinyl)-1-hexanone. It has an empirical formula C17H25NO and a relative molar mass of 259.39 grams. It is available as a racemic mixture.

After administration of MPHP to rats and analysis of urine samples MPHP was found to be metabolised by hydroxylation of the tolyl methyl followed by dehydrogenation to the carboxylic acid. The side chain and pyrrolidine ring also underwent hydroxylation.

After hydroxylation of the pyrrolidine ring it is either dehydrogenated to a lactam ring or the keto group is reduced. The hyrdroxyl and carboxyl groups produced at the first stage of metabolism were only partially conjugated at the second phase of metabolism.

MPHP is not fit for human or animal consumption.

MPHP has been sold as a designer drug and is presumed to cause stimulation.

It is worth noting that para-methylated derivatives of alpha-PHP such as MPHP and MPPP may produce fatal liver damage. The para methyl group in MPHP IS metabolised at the liver by cytochrome P450 enzymes. This is thought to produce toxic by-products. Chemicals without the para-methyl substitution will be less harmful at the liver.

This series of compounds has been associated with addiction.




Buy MPHP for sale in crystals

Buy MPHP for sale in crystals

Buy MPHP for sale in crystals

Buy MPHP for sale in crystals

Buy MPHP for sale in crystals

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100g, 250g, 500g, 1000g


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